Li J, Wang D, Dong J, Jiang R, Zhang K, Zhang S, Zhao H, Sun F
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA.
Genet Epidemiol. 2001;21 Suppl 1:S632-7. doi: 10.1002/gepi.2001.21.s1.s632.
We develop a score statistic to test for linkage in the presence of linkage disequilibrium for quantitative traits. We then extend this method to analyze multiple tightly linked markers. One potential limitation with the use of many genetic markers is the large number of degrees of freedom involved that may reduce the overall power to detect linkage. To overcome this limitation, we propose to group haplotypes on the basis of haplotype similarity before performing transmission disequilibrium tests. Finally, we apply these methods to the Genetic Analysis Workshop 12 simulated data and compare their power.
我们开发了一种评分统计量，用于在存在连锁不平衡的情况下对数量性状进行连锁检验。然后，我们扩展了该方法以分析多个紧密连锁的标记。使用许多遗传标记的一个潜在限制是涉及的自由度数量很大，这可能会降低检测连锁的总体效能。为了克服这一限制，我们建议在进行传递不平衡检验之前，根据单倍型相似性对单倍型进行分组。最后，我们将这些方法应用于遗传分析研讨会12的模拟数据，并比较它们的效能。
