Hinrichs A, Reich T
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Genet Epidemiol. 2001;21 Suppl 1:S662-7. doi: 10.1002/gepi.2001.21.s1.s662.
We report a Markov chain Monte Carlo analysis of the five simulated quantitative traits in Genetic Analysis Workshop 12 using the Loki software. Our objectives were to determine the efficacy of the Markov chain Monte Carlo method and to test a new scoring technique. Our initial blind analysis, on replicate 42 (the "best replicate") successfully detected four out of the five disease loci and found no false positives. A power analysis shows that the software could usually detect 4 of the 10 trait/gene combinations at an empirical point-wise p-value of 1.5 x 10(-4).
我们报告了使用Loki软件对遗传分析研讨会12中的五个模拟数量性状进行的马尔可夫链蒙特卡罗分析。我们的目标是确定马尔可夫链蒙特卡罗方法的有效性，并测试一种新的评分技术。我们对第42次重复（“最佳重复”）进行的初始盲法分析成功检测到了五个疾病位点中的四个，且未发现假阳性。功效分析表明，该软件通常能够在经验逐点p值为1.5×10⁻⁴时检测到10个性状/基因组合中的4个。
