使用方差成分法评估连锁的软件包比较。

A comparison of software packages that assess linkage using a variance components approach.

作者信息

Atkinson E J, Hall D, de Andrade M

机构信息

Department of Health Sciences Research, Section of Biostatistics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

出版信息

Genet Epidemiol. 2001;21 Suppl 1:S81-8. doi: 10.1002/gepi.2001.21.s1.s81.

DOI:10.1002/gepi.2001.21.s1.s81

PMID:11793783

Abstract

We report single-point and multipoint results from three statistical genetics software packages using a variance components approach for quantitative traits. When possible, we have shown the effects of covariates. Results from GENEHUNTER, SOLAR, and ACT software packages are compared for the quantitative trait immunoglobulin E (IgE) using chromosome 5 asthma familial data from Oxfordshire (England), Perth (Australia), and Freiburg (Germany), and using the genome-wide German data. Although few differences among variance components results for GENEHUNTER, SOLAR, and ACT were detected on a limited region of chromosome 5, these packages showed larger disagreement in the German data for chromosomes 1, 9, and 14.

摘要

我们报告了三个统计遗传学软件包使用方差成分法对数量性状进行单点和多点分析的结果。在可能的情况下，我们展示了协变量的影响。使用来自牛津郡（英国）、珀斯（澳大利亚）和弗莱堡（德国）的5号染色体哮喘家族数据以及全基因组德国数据，对GENEHUNTER、SOLAR和ACT软件包关于数量性状免疫球蛋白E（IgE）的结果进行了比较。尽管在5号染色体的有限区域内，GENEHUNTER、SOLAR和ACT的方差成分结果差异不大，但这些软件包在1号、9号和14号染色体的德国数据上显示出更大的分歧。