汇总连锁分析中的加权方案。

Weighting schemes in pooled linkage analysis.

作者信息

Loesgen S, Dempfle A, Golla A, Bickeböller H

机构信息

Institute of Epidemiology, GSF-National Research Center for Environment and Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.

出版信息

Genet Epidemiol. 2001;21 Suppl 1:S142-7. doi: 10.1002/gepi.2001.21.s1.s142.

DOI:10.1002/gepi.2001.21.s1.s142

PMID:11793657

Abstract

To identify susceptibility gene regions for complex diseases a combined linkage analysis of several genome scans might give additional insights to individual studies. In this article we consider different weighting schemes to combine the score statistics of individual studies to an overall statistic within multipoint nonparametric linkage analysis by GENEHUNTER/ALLEGRO. With the Genetic Analysis Workshop (GAW) 12 asthma data sets the weights are dominated by the large differences in the relevant sample sizes.

摘要

为了识别复杂疾病的易感基因区域，对多个基因组扫描进行联合连锁分析可能会为个体研究提供更多见解。在本文中，我们考虑了不同的加权方案，以便在GENEHUNTER/ALLEGRO的多点非参数连锁分析中将个体研究的得分统计量合并为一个总体统计量。对于遗传分析研讨会（GAW）12哮喘数据集，权重主要由相关样本量的巨大差异决定。