Cabral V L, de Carvalho L, Miszputen S J
Departamento de Medicina Clínica, Disciplina de Gastroenterologia, Escola Paulista de Medicina-UNIFESP-EPM.
Arq Gastroenterol. 2001 Apr-Jun;38(2):104-8. doi: 10.1590/s0004-28032001000200005.
The serum albumin concentration has frequently been regarded as an indicator of nutritional status, although the hypoalbuminemia may reflect an acute phase protein response during inflammation mediated by cytokines. Both hypoalbuminemia and malnutrition are observed in Crohn's disease.
To correlate the serum albumin values to disease activity and also to nutritional status in patients with Crohn's disease.
PATIENTS/METHODS: Thirty six patients were studied. Nutritional status was assessed by anthropometry measures and inflammatory activity determined by Harvey's simple clinical index and erythrocyte sedimentation rate.
No correlation was found between malnutrition and hypoalbuminemia. The serum albumin levels correlated inversely with the disease activity. Hypoalbuminemia was 100% sensitive for detection of disease activity.
This study suggests that serum albumin concentration is a very sensitive marker of inflammatory activity and not good indicator of the nutritional status in Crohn's disease. It is necessary a suitable laboratorial parameter for routine nutrition assessment in patients with this inflammatory bowel disease.
血清白蛋白浓度常被视为营养状况的指标，尽管低白蛋白血症可能反映细胞因子介导的炎症过程中的急性期蛋白反应。克罗恩病患者中可观察到低白蛋白血症和营养不良。
将克罗恩病患者的血清白蛋白值与疾病活动度及营养状况相关联。
患者/方法：研究了36例患者。通过人体测量评估营养状况，并用哈维简易临床指数和红细胞沉降率测定炎症活动度。
未发现营养不良与低白蛋白血症之间存在相关性。血清白蛋白水平与疾病活动度呈负相关。低白蛋白血症对疾病活动度检测的敏感性为100%。
本研究提示，血清白蛋白浓度是炎症活动度的非常敏感的标志物，但不是克罗恩病营养状况的良好指标。对于这种炎症性肠病患者的常规营养评估，需要合适的实验室参数。
