Kurkuri M D, Kulkarni A R, Kariduraganavar M Y, Aminabhavi T M
Department of Chemistry, Karnatak University, Dharwad, India.
Drug Dev Ind Pharm. 2001 Nov;27(10):1107-14. doi: 10.1081/ddc-100108373.
Polymeric sodium alginate interpenetrating network membranes containing verapamil hydrochloride were fabricated for transdermal application. The membranes were evaluated for their physical properties, weight and thickness uniformity, water vapor transmission, as well as drug content uniformity. All the thin patches were transparent, smooth, and flexible. The drug-loaded membranes were analyzed by X-ray diffraction to understand the drug polymorphism inside the membrane. The transdermal patches were permeable to water vapor, indicating the permeability characteristics of the polymers. The in vitro drug release was performed in distilled water using a Keshary-Chien diffusion cell. The release data were analyzed to understand the mechanism of drug release.
制备了含有盐酸维拉帕米的海藻酸钠聚合物互穿网络膜用于经皮给药。对这些膜的物理性质、重量和厚度均匀性、水蒸气透过率以及药物含量均匀性进行了评估。所有的薄贴剂均透明、光滑且柔韧。通过X射线衍射分析载药膜，以了解膜内药物的多晶型情况。经皮贴剂具有水蒸气透过性，表明了聚合物的渗透特性。使用Keshary-Chien扩散池在蒸馏水中进行体外药物释放实验。对释放数据进行分析以了解药物释放机制。
