Debray M, Hanslik T, Avansi M A, Pabion B, Lortholary O
Département de médecine communautaire, CHU, BP 217, 38043 Grenoble, France.
Rev Med Interne. 2001 Dec;22(12):1188-95. doi: 10.1016/s0248-8663(01)00490-8.
Only leprosy resource centres undertake surgery for neuritis. Patients' accessibility to this surgical procedure is poor because these centres are often far from their homes. The aim of our work is to study the feasibility of neuritis surgery in the field.
A surgeon trained in this surgery was recruited by Bom-Pastor hospital in Brazilian Amazonia, which is located 400 km away from the leprosy resource centre. Patients operated from May 1996 to December 1997 were enrolled in this retrospective study.
A total of 45 operations were carried out during 17 procedures on 13 patients, among which 12 were multibacillary cases. The decompression surgery was performed with a median delay of 1 year after leprosy diagnosis and 3.5 months after the neuritis diagnosis. Among 17 operations, 14 were performed for painful neuritis of recent onset unsuccessfully treated with corticoids or recurring during the month after corticoids were withdrawn. The other three operations were performed for long-standing neuritis with paralysis and deformity. Pain was relieved in all the cases of recent neuritis, except for one patient who suffered from a serious steroid-dependant erythema nodosum leprosum. An improvement of motor function was observed in one out of three patients with long-standing neuritis. Adverse effects were few: a scar infection with a rapid recovery and a keloid scar. Two neurites recurred 2 and 10 months after the surgery.
In an endemic leprosy region, field access to surgery for neuritis appears to prove real progress in the management of leprosy neuritis.
只有麻风病资源中心开展神经炎手术。由于这些中心往往离患者的家很远,患者获得这种外科手术的机会很少。我们这项工作的目的是研究在当地开展神经炎手术的可行性。
距离麻风病资源中心400公里的巴西亚马孙地区的博姆 - 帕斯托医院招募了一名接受过这种手术培训的外科医生。对1996年5月至1997年12月期间接受手术的患者进行了这项回顾性研究。
在13例患者的17次手术过程中总共进行了45次操作,其中12例为多菌型病例。减压手术在麻风病诊断后中位延迟1年、神经炎诊断后3.5个月进行。在17次手术中,14次是针对近期发生的疼痛性神经炎进行的,这些神经炎用皮质类固醇治疗无效或在停用皮质类固醇后的当月复发。另外3次手术是针对伴有瘫痪和畸形的长期神经炎进行的。除1例患有严重类固醇依赖性结节性红斑麻风的患者外,所有近期神经炎患者的疼痛均得到缓解。在3例长期神经炎患者中,有1例观察到运动功能有所改善。不良反应很少:1例瘢痕感染但恢复迅速,还有1例瘢痕疙瘩。2条神经在术后2个月和10个月复发。
在麻风病流行地区,在当地开展神经炎手术似乎在麻风性神经炎的治疗方面取得了切实进展。