[Transformation of mycosis fungoides to pleomorphic T-cell lymphoma and central nervous system involvement].
作者信息
Guilloton L, Drouet A, Estival J L, Saint Pierre G, Dupin M, Ribot C
机构信息
Service de neurologie, hôpital d'instruction des armées Desgenettes, 108, boulevard Pinel, 69275 Lyon, France. laurent
出版信息
Rev Med Interne. 2001 Dec;22(12):1244-7. doi: 10.1016/s0248-8663(01)00496-9.
INTRODUCTION
Although mycosis fungoides is a malignant T-cell lymphoma involving mainly the skin, neurological complications are possible, with a poor prognosis.
EXEGESIS
A 59-year-old man, treated for mycosis fungoides with transformation to a pleomorphic T-cell lymphoma for 1 year, was seen for mental status changes with confusion. A brain parenchyma localisation was found.
CONCLUSION
This observation emphasizes the exceptional neurological tropism in the patients with mycosis fungoides. A transformation to a more aggressive cutaneous T-cell lymphoma seems necessary to induce a central nervous system involvement.
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