[原发性甲状旁腺功能亢进症，运动神经元疾病的鉴别诊断]
[Primary hyperparathyroidism, a differential diagnosis of motor neuron diseases].
作者信息
Delmont E, Roth S, Heudier P, Cua E, Kaphan R, Campagni J P, Lienhard-Labaune C, Heerding D, Fuzibet J G
机构信息
Service de neurologie, hôpital Pasteur, CHU, avenue de la Voie Romaine, BP 69, 06002 Nice, France.
出版信息
Rev Med Interne. 2001 Dec;22(12):1253-5. doi: 10.1016/s0248-8663(01)00498-2.
INTRODUCTION
Motor neuron diseases are always lethal. Other curable causes of neurologic disorders have to be sought. We report an example.
EXEGESIS
A 72-year-old man presented a distal weakness and atrophy of the upper extremities. Electromyography showed thenar and hypothenar denervation, without fasciculation. Hypercalcemia led to the discovery of a primary hyperparathyroidism. Five months after parathyroid surgery, there was no worsening.
CONCLUSION
Von Recklinghausen and Vical were the first to describe neuromuscular involvement in primary hyperparathyroidism. Faced with symptoms mimicking motor neuron diseases, calcium and phosphorus levels have to be measured because hyperparathyroidism can be cured and neurologic disorders disappear after surgery.
引言
运动神经元疾病通常是致命的。必须寻找其他可治愈的神经系统疾病病因。我们报告一个病例。
病例分析
一名72岁男性出现上肢远端无力和萎缩。肌电图显示鱼际肌和小鱼际肌失神经支配，无肌束震颤。高钙血症导致发现原发性甲状旁腺功能亢进。甲状旁腺手术后五个月，病情未恶化。
结论
冯·雷克林豪森和维卡尔最早描述了原发性甲状旁腺功能亢进的神经肌肉受累情况。面对类似运动神经元疾病的症状时，必须检测钙和磷水平，因为甲状旁腺功能亢进可治愈，术后神经系统疾病可消失。
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