舍曲林、帕罗西汀和文拉法辛用于伴有抑郁症状的难民创伤后应激障碍

Sertralilne, paroxetine and venlafaxine in refugee post traumatic stress disorder with depression symptoms.

作者信息

Smajkić A, Weine S, Durić-Bijedić Z, Boskailo E, Lewis J, Pavković I

机构信息

Project on Genocide, Psychiatry and Witnessing, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA.

出版信息

Med Arh. 2001;55(1 Suppl 1):35-8.

PMID:11795192

Abstract

The authors describe the use of three new antidepressants: Sertralilne, Paroxetine and Venlafaxine in treating Posttraumatic Stress Disorder and symptoms of Depression in adult Bosnian refugees victims of ethnic cleansing. 32 Bosnian refugees with PTSD and symptoms of Depression presenting for treatment of the mental health consequences of surviving ethnic cleansing, participated in a case series study. All subjects completed open trials of Sertraline (15), Paroxetine (12) or Venlafaxine (5), with standard clinical doses. Overall, Sertraline and Paroxetine yielded statistically significant improvement at 6 weeks in the total PTSD symptom severity, in each symptom cluster, in Beck Depression Inventory and in Global Assessment of Functioning. Venlafaxine produced statistically significant improvement at 6 weeks in the total PTSD symptom severity, in each symptom cluster and in Global Assessment of Functioning but did not yield significant improvement in symptoms of depression and had a high rate of side effects.

摘要

作者描述了三种新型抗抑郁药（舍曲林、帕罗西汀和文拉法辛）在治疗波斯尼亚成年难民（种族清洗受害者）创伤后应激障碍及抑郁症状中的应用。32名患有创伤后应激障碍及抑郁症状的波斯尼亚难民参与了一项病例系列研究，他们因种族清洗幸存下来而出现心理健康问题前来接受治疗。所有受试者均完成了舍曲林（15例）、帕罗西汀（12例）或文拉法辛（5例）的开放试验，采用标准临床剂量。总体而言，舍曲林和帕罗西汀在6周时使创伤后应激障碍症状严重程度总分、各症状群、贝克抑郁量表及功能总体评定方面均有统计学意义的改善。文拉法辛在6周时使创伤后应激障碍症状严重程度总分、各症状群及功能总体评定方面有统计学意义的改善，但在抑郁症状方面未产生显著改善，且副作用发生率较高。