Langer M, Madeddu G, Costanza C
Clin Endocrinol (Oxf). 1979 Oct;11(4):461-4. doi: 10.1111/j.1365-2265.1979.tb03097.x.
Total and free thyroid hormones (T3, T4, FT3 and FT4), TSH and its response to TRH were determined in sixty-three patients affected by autonomous thyroid nodules: mean concentrations of free T3 (FT3) were significantly higher in hot nodules (suppressing extranodular tissue on the scan) as compared to warm ones, even in those cases where total T3 and T4 were within normal ranges (hot nodules, group as a whole: 8.8 +/- 3.5 pg/ml; warm nodules: 5.3 +/- 1.2; hot nodules with normal total T3 and T4 concentrations: 7.5 +/- 3). Also the clinical condition of thyrotoxicosis appeared to be correlated with FT3 concentrations (toxic patients, group as a whole: 9.6 +/- 4.0 pg/ml; euthyroid patients: 6.8 +/- 3.1; toxic patients with normal values of T3 and T4; 8.3 +/- 2.8). On the contrary the correlation of total and free thyroid hormone concentrations with the response of TSH to TRH was not significant.
对63例患有自主性甲状腺结节的患者测定了总甲状腺激素和游离甲状腺激素（T3、T4、FT3和FT4）、促甲状腺激素（TSH）及其对促甲状腺激素释放激素（TRH）的反应：与温结节相比，热结节（扫描时抑制结节外组织）中的游离T3（FT3）平均浓度显著更高，即使在总T3和T4处于正常范围的情况下也是如此（热结节，整个组：8.8±3.5 pg/ml；温结节：5.3±1.2；总T3和T4浓度正常的热结节：7.5±3）。甲状腺毒症的临床状况似乎也与FT3浓度相关（甲状腺毒症患者，整个组：9.6±4.0 pg/ml；甲状腺功能正常的患者：6.8±3.1；T3和T4值正常的甲状腺毒症患者：8.3±2.8）。相反，总甲状腺激素和游离甲状腺激素浓度与TSH对TRH的反应之间的相关性不显著。
