通过铑催化串联氢甲酰化/缩醛化反应合成呋喃并[2,3 - b]呋喃和呋喃并[2,3 - b]吡喃。
Synthesis of furo[2,3b]furans and furo[2,3b]pyrans via rhodium-catalyzed tandem hydroformylation/acetalization.
作者信息
Roggenbuck Rafael, Schmidt Andreas, Eilbracht Peter
机构信息
Fachbereich Chemie, Organische Chemie I, Universität Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.
出版信息
Org Lett. 2002 Jan 24;4(2):289-91. doi: 10.1021/ol017083o.
PMID:11796072
Abstract
[reaction: see text] Rhodium-catalyzed tandem hydroformylation/acetalization of alpha,omega-alkenediols gives facile access to perhydrofuro[2,3b]furans and perhydrofuro[2,3b]pyrans in good yields. Similarly, benzoannelated tetrahydrofuro[2,3b]furans are obtained by hydroformylation of o-hydroxy cinnamyl alcohols.
摘要
[反应：见正文] 铑催化的α,ω-烯二醇串联氢甲酰化/缩醛化反应能够简便地以良好产率得到全氢呋喃并[2,3 - b]呋喃和全氢呋喃并[2,3 - b]吡喃。类似地，通过邻羟基肉桂醇的氢甲酰化反应可得到苯并稠合的四氢呋喃并[2,3 - b]呋喃。
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