Neufeld Gera, Cohen Tzafra, Shraga Niva, Lange Tali, Kessler Ofra, Herzog Yael
Department of Biology, Technion, Israel Institute of Technology, Haifa, Israel.
Trends Cardiovasc Med. 2002 Jan;12(1):13-9. doi: 10.1016/s1050-1738(01)00140-2.
The neuropilin-1 (np1) and neuropilin-2 (np2) receptors function as receptors for the axon guidance factors belonging to the class-3 semaphorin subfamily. In addition, both neuropilins are able to bind to certain heparin-binding splice forms of vascular endothelial growth factor (VEGF), indicating that both neuropilins have roles in the cardiovascular system as well. Gene targeting experiments indicate that np1 does indeed function as an important modulator of VEGF function during vasculogenesis and angiogenesis, but the role of np2 in the cardiovascular system has not been studied in detail as yet. This review focuses on the neuropilins, their interactions, and their biological roles in the nervous and cardiovascular systems.
神经纤毛蛋白-1（np1）和神经纤毛蛋白-2（np2）受体作为3类信号素亚家族轴突导向因子的受体发挥作用。此外，这两种神经纤毛蛋白都能够结合血管内皮生长因子（VEGF）的某些肝素结合剪接形式，这表明这两种神经纤毛蛋白在心血管系统中也发挥作用。基因靶向实验表明，np1在血管生成和血管新生过程中确实作为VEGF功能的重要调节因子发挥作用，但np2在心血管系统中的作用尚未得到详细研究。本综述重点关注神经纤毛蛋白、它们的相互作用以及它们在神经和心血管系统中的生物学作用。
