显性负性Rho、Rac和Cdc42促进副溶血性弧菌侵入Caco-2细胞的过程。
Dominant-negative Rho, Rac, and Cdc42 facilitate the invasion process of Vibrio parahaemolyticus into Caco-2 cells.
作者信息
Akeda Yukihiro, Kodama Toshio, Kashimoto Takashige, Cantarelli Vlademir, Horiguchi Yasuhiko, Nagayama Kenichi, Iida Tetsuya, Honda Takeshi
机构信息
Department of Bacterial Infections. Department of Bacterial Toxinology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
出版信息
Infect Immun. 2002 Feb;70(2):970-3. doi: 10.1128/IAI.70.2.970-973.2002.
Abstract
To clarify the invasive process of Vibrio parahaemolyticus, an invasion assay was performed using cells expressing dominant negative small GTPases of the Rho family. This assay showed that the dominant negative host phenotype facilitates bacterial invasion, suggesting that the mechanism of V. parahaemolyticus invasion differs from that reported for other invasive bacteria.
摘要
为阐明副溶血性弧菌的侵袭过程，利用表达Rho家族显性负性小GTP酶的细胞进行了侵袭试验。该试验表明，显性负性宿主表型促进细菌侵袭，这表明副溶血性弧菌的侵袭机制与其他侵袭性细菌的报道不同。
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