Fu Y, Niu D, Ruan H, Yu X P, Chen G, He G Q
Animal Science College of Zhejiang University, Hangzhou 310029, China.
Yi Chuan Xue Bao. 2001;28(12):1129-36.
The aim of this study was to investigate the action of activin and follistatin either alone or in combination on FSH receptor mRNA expression. The results showed that activin alone increased FSH receptor mRNA level in the presence or absence of FSH in cultured granulosa cells, and the stimulating effect of activin on FSH receptor level was dose-dependent. This effect of activin was inhibited by FSP treatment which alone had no effect on FSH receptor expression. From the results, it can be concluded that activin and follistatin both exert autocrine actions on granulosa cells, and the two factors, possibly by regulating FSH receptor expression, may play important roles in follicular development.
本研究的目的是调查激活素和卵泡抑素单独或联合作用对促卵泡激素（FSH）受体mRNA表达的影响。结果显示，在培养的颗粒细胞中，无论有无FSH，单独使用激活素均可增加FSH受体mRNA水平，且激活素对FSH受体水平的刺激作用呈剂量依赖性。激活素的这种作用被卵泡抑素相关蛋白（FSP）处理所抑制，而FSP单独对FSH受体表达无影响。从结果可以得出结论，激活素和卵泡抑素均对颗粒细胞发挥自分泌作用，这两种因子可能通过调节FSH受体表达，在卵泡发育中发挥重要作用。
