Kawashima O, Kakegawa S, Otani Y, Kamiyoshihara M, Sugano M, Morishita Y
Department of Thoracic Surgery, National Nishigunma Hospital, Shibukawa, Japan.
Kyobu Geka. 2002 Jan;55(1):20-4.
We evaluated retrospectively 33 patients with synchronous multiple primary lung cancers. These were 20 men and 13 women, with a mean age of 67 years (range, 51-79 years). In 27 cases, the tumors were located in the ipsilateral lung, and in 6 cases, they were in the bilateral lung. In patients with synchronous multiple primary lung cancers, combinations of adenocarcinoma and adenocarcinoma (12 cases, 36.4%), adenocarcinoma and others (6 cases, 18.2%) were most commonly observed histologically. Lobectomy was performed in 18, bi-lobectomy in 3, pneumonectomy in 4, lobectomy with partial resection in 6, and lobectomy with laser therapy or irradiation in 2 patients. Overall 5-year survival rate of this disease was 78.3%. Eight patients died within 1 year after surgical resection, and 2 of them died of treatment-related accident. Although optimal treatment of choice for synchronous multiple primary lung cancers remains an unresolved problem, we think that careful planning of the treatment for this disease including selection of surgical methods is much important.
我们回顾性评估了33例同时性多原发性肺癌患者。其中男性20例，女性13例，平均年龄67岁（范围51 - 79岁）。27例肿瘤位于同侧肺，6例位于双侧肺。在同时性多原发性肺癌患者中，组织学上最常观察到的是腺癌与腺癌的组合（12例，36.4%）、腺癌与其他类型的组合（6例，18.2%）。18例行肺叶切除术，3例行双肺叶切除术，4例行全肺切除术，6例行肺叶切除加部分切除术，2例行肺叶切除加激光治疗或放疗。该疾病的总体5年生存率为78.3%。8例患者在手术切除后1年内死亡，其中2例死于与治疗相关的意外。尽管同时性多原发性肺癌的最佳治疗选择仍是一个未解决的问题，但我们认为对此类疾病进行仔细的治疗规划，包括手术方法的选择非常重要。
