Wang J, Wang Y
Beijing Huilongguan Hospital, Beijing 100096.
Zhonghua Nei Ke Za Zhi. 1999 Oct;38(10):663-5.
To investigate the neuropsychological pattern of different dementia severity in Alzheimer Disease (AD).
Probable AD patients who were examined with NINCDS-ADRDA criteria for clinical diagnosis of AD were further examined with several neuropsychological tests and the dementia severity was determined with clinical dementia rating (CDR).
There was impairement of visuospatial function in mild AD (CDR = 1). Evident decline was found in moderately severe AD (CDR = 2) and severe AD (CDR = 3). There was impairment of cognition function in mild AD and the decline continued in moderately severe and severe AD. Memory function declined apparently in the early stage of AD, but the decline was not apparent in moderately severe AD. However, the decline became very quick and memory function was completely lost in severe AD. The trend of decline of daily living activity and ability was the same as memory. Alteration in personality appeared in the mild AD and became most evident in severe AD.
Neuropsychological test is useful in diagnosis of AD in the early stage, and neuropsychological pattern in each stage is useful in differential diagnosis.
研究阿尔茨海默病（AD）不同痴呆严重程度的神经心理学模式。
根据NINCDS - ADRDA标准接受临床诊断为AD的疑似AD患者，进一步接受多项神经心理学测试，并通过临床痴呆评定量表（CDR）确定痴呆严重程度。
轻度AD（CDR = 1）存在视觉空间功能损害。中度严重AD（CDR = 2）和重度AD（CDR = 3）出现明显下降。轻度AD存在认知功能损害，在中度严重和重度AD中这种下降仍在持续。AD早期记忆功能明显下降，但在中度严重AD中下降不明显。然而，在重度AD中下降变得非常迅速且记忆功能完全丧失。日常生活活动和能力的下降趋势与记忆相同。轻度AD出现人格改变，在重度AD中最为明显。
神经心理学测试有助于AD的早期诊断，各阶段的神经心理学模式有助于鉴别诊断。
