Meng Z, Yao J, Zhao Y
Hebei Province Sanitary and Anti-epidemic Station, Baoding 071000, China.
Zhonghua Yi Xue Za Zhi. 2000 Jan;80(1):9-11.
To further survey the protective efficacy of the standard attenuated live hepatitis A vaccines (H(2) strain).
Randomized and controlled trials were performed in Fucheng county, Hebei province. A total of 12 036 children were assigned into vaccine group (5 551) and control group (6 485) by cluster sampling. The morbidity of hepatitis A was observed and the blood was collected once hepatitis A showed epidemic to detect anti-HAV IgG and IgM.
During the period of the first 7 months after vaccination, hepatitis A was sporadic, the morbidity of hepatitis A was 0.55/100 000, and only 1 case occurred in the control group and no case in the vaccine group. From January to August 1998, hepatitis A showed epidemic in a township of this county. The morbidities were 0.37% and 6.69% for vaccine group and control group, respectively. The protective efficacy of the vaccine was 94.47%. The ratios of clinical cases to subclinical infections were 1 to 11 and 1 to 1 for vaccine and control groups, respectively (P < 0.05).
The H(2) strain vaccine has a very good protective efficacy, and obviously decreases the attack rate, new infection rate and clinical cases by HAV infection.
进一步观察甲型肝炎标准减毒活疫苗（H2株）的保护效果。
在河北省阜城县进行随机对照试验。通过整群抽样将12036名儿童分为疫苗组（5551名）和对照组（6485名）。观察甲型肝炎发病率，在甲型肝炎流行时采集血液检测抗-HAV IgG和IgM。
接种疫苗后的前7个月内，甲型肝炎呈散发，甲型肝炎发病率为0.55/10万，对照组仅发生1例，疫苗组无病例发生。1998年1月至8月，该县某乡甲型肝炎流行。疫苗组和对照组的发病率分别为0.37%和6.69%。疫苗的保护效果为94.47%。疫苗组和对照组临床病例与亚临床感染的比例分别为1:11和1:1（P<0.05）。
H2株疫苗具有很好的保护效果，能明显降低甲型肝炎病毒感染的发病率、新感染率和临床病例数。
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