Wang X, Meng Z, Li R
Shanghai Medical University, Shanghai 200032, China.
Zhonghua Yi Xue Za Zhi. 2000 Jun;80(6):422-4.
To study the immunology effects of live attenuated hepatitis A vaccine in different doses and schedules groups, and compare with inactivated hepatitis A vaccine (Havrix, Smithkline).
318 susceptible children were enrolled in Guangxi and Hebei province. These subjects were divided into six groups. Each group was vaccinated with either inactivated vaccine or different doses and schedules of live attenuated vaccine. Serum specimens were collected and tested for anti-HAV antibody at different time after the vaccination.
GMT of each group arrived at the peak 1 months after re-vaccination, then declined, and GMT of 6 months after booster dose was still significantly higher than that after primary immunization. Sero-conversion rates in all groups reached 100% after a booster dose, and kept at 6 months after booster dose.
A booster dose of live attenuated vaccine can induce secondary immune response well. The immunology effects after booster dose are comparable with inactivated vaccine and it should be useful to the immune persistence.
研究不同剂量和程序的甲型肝炎减毒活疫苗的免疫学效果，并与甲型肝炎灭活疫苗（史克必成公司生产的贺福立适）进行比较。
选取广西和河北省的318名易感儿童。这些受试者被分为六组。每组分别接种灭活疫苗或不同剂量和程序的减毒活疫苗。在接种疫苗后的不同时间采集血清标本并检测抗甲型肝炎病毒抗体。
每组的几何平均滴度（GMT）在再次接种后1个月达到峰值，然后下降，加强免疫后6个月的GMT仍显著高于初次免疫后。所有组在加强免疫后血清转化率均达到100%，并在加强免疫后6个月保持该水平。
一剂甲型肝炎减毒活疫苗加强免疫可良好诱导二次免疫应答。加强免疫后的免疫学效果与灭活疫苗相当，且对免疫持久性有益。
