糖耐量受损的OLETF大鼠胰岛结构与功能变化及糖脂代谢异常的关系

[Relationship between structural and functional changes of islets, and abnormal metabolism of glucose and lipids in OLETF rats with impaired glucose tolerance].

作者信息

Liu Y, Xu Z, Zhang J

机构信息

Department of endocrinology, 306th Hospital of PLA, Beijing 100101, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2000 Mar;80(3):175-7.

PMID:11798752

Abstract

OBJECTIVE

To investigate the level of blood glucose, cholesterol (Cho), triglycerides (TG), insulin secretion and the efficacy of acarbose in preventing impaired glucose tolerance (IGT) in Otsuka Long-Events Tokushima Fatty (OLETF) rats.

METHODS

10 OLETF rats with IGT, 8 IGT OLETF rats with acarbose treatment, and 36 LETO rats with normal glucose level were observed for their blood glucose, Cho, TG, insulin secretion and histological changes in the pancreas and skeletal muscles.

RESULTS

OLETF rats with IGT were mild obese, with fat infiltration in the islets and skeletal muscles. Their blood Cho and TG were higher than those of LETO rats (2.5 mmol/L +/- 0.3 mmol/L vs 2.1 mmol/L +/- 0.3 mmol/L, P < 0.01; 0.7 mmol/L +/- 0.2 mmol/L vs 0.4 +/- 0.2 mmol/L, P < 0.01), but their TG was lower than that of diabetic rats (1.8 +/- 1.0). The Cho, TG and post-challenge glucose levels were normal in the IGT rats with 4-week acarbose treatment, with their insulin secretion and glucose tolerance improved and fat infiltration decreased.

CONCLUSION

Acarbose can prevent obesity and fat infiltration in islets and muscles, improve glucose and lipid metabolism, and insulin secretion in OLETF rats with IGT.

摘要

目的

研究大冢长期高脂血症德岛肥胖（OLETF）大鼠的血糖、胆固醇（Cho）、甘油三酯（TG）水平、胰岛素分泌情况以及阿卡波糖预防糖耐量受损（IGT）的疗效。

方法

观察10只患有IGT的OLETF大鼠、8只接受阿卡波糖治疗的IGT OLETF大鼠以及36只血糖水平正常的LETO大鼠的血糖、Cho、TG、胰岛素分泌情况，以及胰腺和骨骼肌的组织学变化。

结果

患有IGT的OLETF大鼠轻度肥胖，胰岛和骨骼肌有脂肪浸润。其血液Cho和TG高于LETO大鼠（2.5 mmol/L ± 0.3 mmol/L对2.1 mmol/L ± 0.3 mmol/L，P < 0.01；0.7 mmol/L ± 0.2 mmol/L对0.4 ± 0.2 mmol/L，P < 0.01），但其TG低于糖尿病大鼠（1.8 ± 1.0）。接受4周阿卡波糖治疗的IGT大鼠的Cho、TG和餐后血糖水平正常，胰岛素分泌和糖耐量改善，脂肪浸润减少。