Liang X, Zhuang G, Zhou C
First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China.
Zhonghua Yi Xue Za Zhi. 2001 Jul 10;81(13):819-21.
To study the basal FSH/LH ratio and its changes to prognosticate the ovary reserve.
891 regularly cycling patients (IVF) participate. They were divided into three groups (the cancellation group which included using gonadotrophins one week later, there were 3 or less follicles to growth on ultrasound examination: 70cycles; the low response group defined as the collection of fewer or equal than 4 oocytes: 56 cycles; normally response group, the collection of more then 4 oocytes: 765 cycles). On the menstruation day 2 - 3 (basal level) and after using GnRHa, serum follicle stimulating hormone (FSH), luteinzing hormone (LH) and estradiol (E2) were demonstrated by immunoassay and analyzed by SPSS, the dose of gonadotrophins (Gn) and the treatment.
The basal FSH levels of cancellation group (9.7 IU/L +/- 7.8 IU/L), the low response group (7.8 IU/L +/- 5.4 IU/L), and normally response group (6.4 IU/L +/- 2.0 IU/L) have significant difference in the three groups P < 0.001. The basal FSH/LH ratio of the cancellation group (2.9), the low response group (2.0), and normally response group (1.6) have significant difference P < 0.05. And after using GnRHa, the 1 - 3 day of menstruation and before starting of Gn, the FSH/LH ratio became more higher in the cancellation group and the low responder group, FSH/LH > 5 and 4 respectively, the normally response group FSH/LH < 3, also there were significantly difference between them P < 0.001. The basal E2 levels in the normal response group were significantly lower than that in the low responder group.
The data suggest that although serum FSH level on D2-D3 doesn't reach 15IU/L, the basal FSH/LH > 2. After using GnRHa, the FSH/LH ratio became significantly higher, and the basal E2 level is higher, which is useful in prognostic assessment of ovarian bad reserve.
研究基础促卵泡激素/促黄体生成素（FSH/LH）比值及其变化以预测卵巢储备功能。
891例规律月经周期的体外受精（IVF）患者参与研究。将其分为三组（取消周期组，即使用促性腺激素一周后，超声检查发现生长卵泡≤3个：70个周期；低反应组，定义为取卵数≤4个：56个周期；正常反应组，取卵数＞4个：765个周期）。在月经第2 - 3天（基础水平）及使用促性腺激素释放激素激动剂（GnRHa）后，采用免疫分析法检测血清促卵泡刺激素（FSH）、促黄体生成素（LH）和雌二醇（E2），并运用SPSS软件分析促性腺激素（Gn）剂量及治疗情况。
取消周期组基础FSH水平为（9.7 IU/L±7.8 IU/L），低反应组为（7.8 IU/L±5.4 IU/L），正常反应组为（6.4 IU/L±2.0 IU/L），三组间差异有统计学意义（P＜0.001）。取消周期组基础FSH/LH比值为2.9，低反应组为2.0，正常反应组为1.6，差异有统计学意义（P＜0.05）。使用GnRHa后，月经第1 - 3天且在开始使用Gn前，取消周期组和低反应组的FSH/LH比值升高更为明显，分别＞5和＞4，正常反应组FSH/LH＜3，组间差异有统计学意义（P＜0.001）。正常反应组的基础E2水平显著低于低反应组。
数据表明，尽管月经第2 - 3天血清FSH水平未达到15 IU/L，但基础FSH/LH＞2。使用GnRHa后，FSH/LH比值显著升高，且基础E2水平较高，这对卵巢储备功能不良的预后评估有帮助。
