白塞病：免疫病理学及治疗方面

Behçet's disease: immunopathologic and therapeutic aspects.

作者信息

Meador Robert, Ehrlich George, Von Feldt Joan M

机构信息

Department of Rheumatology, Hospital of University of Pennsylvania, 3 Ravdin, Suite G, 3400 Spruce Street, Philadelphia, PA, USA.

出版信息

Curr Rheumatol Rep. 2002 Feb;4(1):47-54. doi: 10.1007/s11926-002-0023-z.

DOI:10.1007/s11926-002-0023-z

PMID:11798982

Abstract

Behçet's disease (BD) is a systemic inflammatory disease of unknown etiology. The disease is strongly associated with the human leukocyte antigen (HLA) B51. BD has a chronic course with periodic exacerbations and progressive deterioration. There are no specific diagnostic laboratory tests, although recurrent oral ulceration is an obligatory manifestation for diagnosis. The treatment, which includes local, systemic, or surgical therapies, is based on the severity of the illness; the most appropriate management requires a multidisciplinary approach. This paper summarizes all aspects of BD with particular emphasis on the latest immunologic and treatment aspects.

摘要

白塞病（BD）是一种病因不明的全身性炎症性疾病。该疾病与人类白细胞抗原（HLA）B51密切相关。白塞病病程呈慢性，有周期性加重和进行性恶化。尽管复发性口腔溃疡是诊断的必备表现，但尚无特异性诊断性实验室检查。治疗包括局部、全身或手术治疗，取决于疾病的严重程度；最恰当的管理需要多学科方法。本文总结了白塞病的各个方面，特别强调了最新的免疫学和治疗方面。