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[自然疗法和禁食疗法期间肠道分泌型免疫球蛋白A的变化及患者状况]

[Progression of intestinal secretory immunoglobulin A and the condition of the patients during naturopathic therapy and fasting therapy].

作者信息

Beer A M, Rüffer A, Balles J, Ostermann T

机构信息

Modellabteilung für Naturheilkunde, Klinik Blankenstein, Hattingen.

出版信息

Forsch Komplementarmed Klass Naturheilkd. 2001 Dec;8(6):346-53. doi: 10.1159/000057251.

Abstract

BACKGROUND

In clinical observations it was noticed that patients who have been treated with naturopathic methods - especially with the treatment of heal fasting - experience a stabilization of their immune system. The immune system stands in close relation to the intestinal flora and influences the condition of the patient.

QUESTION

For this reason the influence of a 3-week in-hospital naturopathic therapy - among others a heal-fasting therapy -, a corresponding follow-up on the intestine-associated immune system as well as the condition of the patients have been examined.

PATIENTS AND METHODS

Classical naturopathic treatments based on standardized therapy concepts were applied. The patients (n = 55) showed different kinds of basic diseases, whereof in 56% of the cases the patients suffered of diseases of the skeleton, the muscles, and the connective tissue. The patients got a 3-week standardized high-quality nutrition or they took part in a juice-modified fasting therapy. The state of the local endogenous defense system within the intestine was measured by the concentration of the secretory immunoglobulin A (sIgA) in the feces of the patients. A positive criterion was a sIgA concentration in the stool of under 0.5 mg/g. Additionally the judgement of the patients concerning their own condition ('quality of life') was determined by the condition scale.

RESULTS

It was shown that the content of the sIgA within the stool was increased during the course of the in-hospital stay, in the complete population of patients as well as in the different subgroups 'with heal-fasting' and 'without heal-fasting'. Even in the follow-up analysis it could be observed that 3 months after the treatment the content of secretory IgA in the stool of all groups was between 0.78 and 0.89 mg/g. This value was significantly higher than the starting values. The most intensive effects concerning the change of sIgA were measured within the group of the patients who performed heal fasting (epsilon > 1.0). Aside from the increase of the secretory IgA, a mediocre improvement of the condition of the patients within the pre-post comparison could be noticed, but no correlation between the secretory IgA values and the values concerning the condition was found.

CONCLUSION

A 3-week in-hospital therapy with classical naturopathic treatments (but especially the application of the heal-fasting therapy) leads to a significant improvement of the immune condition of the intestine and consequently of the whole organism. The improving effect lasts beyond the stay in hospital.

摘要

背景

在临床观察中发现,接受自然疗法治疗的患者——尤其是采用治愈性禁食疗法治疗的患者——其免疫系统会趋于稳定。免疫系统与肠道菌群密切相关,并会影响患者的病情。

问题

基于此,研究人员考察了为期3周的住院自然疗法——其中包括治愈性禁食疗法——对肠道相关免疫系统以及患者病情的影响,并进行了相应的随访。

患者与方法

采用基于标准化治疗理念的经典自然疗法。患者(n = 55)患有不同类型的基础疾病,其中56%的患者患有骨骼、肌肉和结缔组织疾病。患者接受了为期3周的标准化优质营养治疗,或者参加了果汁改良禁食疗法。通过检测患者粪便中分泌型免疫球蛋白A(sIgA)的浓度来衡量肠道内局部内源性防御系统的状态。阳性标准是粪便中sIgA浓度低于0.5mg/g。此外,通过病情量表确定患者对自身病情(“生活质量”)的评价。

结果

结果显示,在住院期间,无论是全体患者还是“接受治愈性禁食”和“未接受治愈性禁食”的不同亚组,粪便中sIgA的含量均有所增加。即使在随访分析中也可以观察到,治疗3个月后,所有组粪便中分泌型IgA的含量在0.78至0.89mg/g之间。该值显著高于起始值。在进行治愈性禁食的患者组中,观察到sIgA变化的影响最为显著(ε>1.0)。除了分泌型IgA增加外,在治疗前后的比较中可以注意到患者病情有适度改善,但未发现分泌型IgA值与病情值之间存在相关性。

结论

为期3周的住院经典自然疗法治疗(尤其是采用治愈性禁食疗法)可显著改善肠道免疫状况,进而改善整个机体的免疫状况。这种改善效果在出院后仍持续存在。

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