Lereim P, Langeland N, Romanus B, Pettersen J E, Goldie I F
Acta Orthop Scand. 1975 Sep;46(4):672-84. doi: 10.3109/17453677508989250.
A chemical analysis has been carried out on specimens from the subchondral weightbearing area of the medial tibial condyle from 22 normal individuals, 14 individuals with osteoarthritis and 12 individuals with rheumatoid arthritis. In the normal group there was a decrease in density with advancing age. Over the age of 50 there was no significant difference between the groups. The content of collagen, calcium, phosphorus and magnesium in each bone specimen was calculated. When expressed in per cent of dry fat free bone there was no significant difference between the three groups. When calculations were made on the basis of content per volume tissue wet bone some differences were found. There was a tendency for a higher content of collagen in rheumatoid bone than in normal and osteoarthritic bone. The content of calcium was significantly higher in rheumatoid arthritis than in osteoarthritis; the same result was found in the analysis of phosphorus. In the normal group there was a decrease in phosphorus content with advancing age, this was also seen in the magnesium analysis.
对22名正常个体、14名骨关节炎患者和12名类风湿关节炎患者胫骨内侧髁软骨下负重区的标本进行了化学分析。在正常组中，密度随年龄增长而降低。50岁以上，各组之间无显著差异。计算了每个骨标本中胶原蛋白、钙、磷和镁的含量。以无脂干骨的百分比表示时，三组之间无显著差异。当以每体积组织湿骨的含量进行计算时，发现了一些差异。类风湿骨中的胶原蛋白含量有高于正常骨和骨关节炎骨的趋势。类风湿关节炎患者的钙含量显著高于骨关节炎患者；磷分析也得到了相同结果。在正常组中，磷含量随年龄增长而降低，镁分析中也有此现象。
