Khongphatthanayothin A, Chotivitayatarakorn P, Lertsupcharoen P, Muangmingsuk S, Thisyakorn C
Department of Pediatrics, Faculy of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 2001 Sep;84(9):1321-8.
Ten patients (aged 0-9 years) with the diagnosis of automatic atrial tachycardia (AAT) from August 1997 to August 2000 were reviewed. Three patients had paroxysmal (repetitive) AAT and the tachycardia was incessant in six (defined as presence of AAT for more than 90% of the time). The type of AAT in one patient was unknown. Four patients presented with congestive heart failure (CHF), one with pre-syncope, one with palpitation, and four were asymptomatic. Six patients (60%) had depressed left ventricular ejection fraction. All patients with CHF had incessant AAT with atrial rate > 220/min and ventricular rate > 200/min at admission. After treatment with antiarrhythmic medications, all patients had adequate control of the AAT (9 had complete elimination of AAT and 1 partial control). Amiodarone (alone, or in combination with digoxin) was effective in 5 of 6 cases (83%), although complete elimination of the AAT was usually delayed (median = 5 days, range 30 minutes to 17 days). Other effective medications were digoxin, digoxin + propranolol and atenolol (all in patients who did not have CHF on presentation). At the time of this report, 3 patients had no AAT off antiarrhythmic medication, 5 patients were still receiving treatment (with good control) and 2 patients died from sepsis during the same admission even though AAT was controlled. All surviving patients had normal ventricular ejection fraction on follow-up. AAT in children is rare, but when it occurs in persistent form at a fast rate, it is usually associated with CHF and is difficult to treat. Amiodarone (+/- digoxin) effectively controls the arrhythmia in the majority of cases, although full effect may take several days. With successful treatment, most patients do well and some can be taken off the medication(s) without recurrence of the arrhythmia.
回顾了1997年8月至2000年8月期间诊断为自动性房性心动过速(AAT)的10例患者(年龄0 - 9岁)。3例患者为阵发性(反复性)AAT,6例心动过速持续存在(定义为AAT存在时间超过90%)。1例患者的AAT类型不明。4例患者出现充血性心力衰竭(CHF),1例出现晕厥前症状,1例有心悸,4例无症状。6例患者(60%)左心室射血分数降低。所有CHF患者入院时均有持续的AAT,心房率>220次/分钟,心室率>200次/分钟。经抗心律失常药物治疗后,所有患者的AAT均得到充分控制(9例AAT完全消除,1例部分控制)。胺碘酮(单独使用或与地高辛联合使用)在6例中的5例(83%)有效,尽管AAT的完全消除通常会延迟(中位数 = 5天,范围30分钟至17天)。其他有效的药物有地高辛、地高辛 + 普萘洛尔和阿替洛尔(均用于初诊时无CHF的患者)。在本报告发布时,3例患者在停用抗心律失常药物后无AAT发作,5例患者仍在接受治疗(控制良好),2例患者在同一住院期间死于败血症,尽管AAT已得到控制。所有存活患者随访时心室射血分数正常。儿童AAT罕见,但当以快速持续形式出现时,通常与CHF相关且难以治疗。胺碘酮(±地高辛)在大多数情况下能有效控制心律失常,尽管完全起效可能需要数天。治疗成功后,大多数患者情况良好,一些患者可以停用药物且心律失常不再复发。