Nakayama I, Matsuo T, Oyakawa Y, Takahara O, Tsuji K
Acta Pathol Jpn. 1975 Jul;25(4):439-50. doi: 10.1111/j.1440-1827.1975.tb00864.x.
The fate of castration cells has been studied by electron microscopy after bilateral oophorectomy. The castration cells were characterized by a large-like dilatation of rough endoplasmic reticulum which occupied almost the entire cytoplasm, and first appeared at 5 weeks after operation. Castration cells showed cellular suppression after 15 weeks of the experiment but no degenerative changes were observed at any experimental period. At the later stage of the experiment numerous secretory granules reaccumulated in the cytoplasm of the gonadotrophs and concomitantly lake-like dilatation of rough endoplasmic reticulum in some gonadotrophs gradually decreased and finally disappeared from the cytoplasm. Proportion of the castration cells and mean diameter of the largest cisterane of rough endoplasmic reticulum in each cell attained maximum value at 9 weeks after the operation; thereafter both parameters returned toward normal, although they still remained at a higher level than in controls at 18 weeks after the operation.
通过电子显微镜对双侧卵巢切除术后去势细胞的命运进行了研究。去势细胞的特征是粗面内质网呈大泡状扩张，几乎占据整个细胞质，术后5周首次出现。实验15周后去势细胞显示出细胞抑制，但在任何实验阶段均未观察到退行性变化。在实验后期，促性腺细胞的细胞质中重新积累了大量分泌颗粒，同时一些促性腺细胞中粗面内质网的泡状扩张逐渐减少，最终从细胞质中消失。去势细胞的比例和每个细胞中粗面内质网最大池的平均直径在术后9周达到最大值；此后，尽管在术后18周时这两个参数仍高于对照组，但均恢复至正常水平。
