Ravnskov U, Karátson A
Acta Physiol Scand. 1975 Aug;94(4):467-71. doi: 10.1111/j.1748-1716.1975.tb05906.x.
The plasma disappearance rates of human beta2-microglobulin and (hydroxy-methyl-C14)-inulin was measured in unoperated, sham-operated, ureter-ligated and nephrectomised rats. Judging from the C14-activity curves in ureter-ligated and nephrectomised rats a substantial glomerular filtration continued after obstruction of the urine flow. Almost 90% of the injected protein had disappeared from plasma 120 min after injection into nephrectomised rats indicating a considerable extra-renal elimination and invalidating attempts to evaluate different renal mechanisms of elimination before and after ureter-ligation. Sham-operation induced an increase of the plasma disappearance of both beta2-microglobulin and inulin. The latter phenomenon may explain earlier findings of similarity between the disappearance curves of low molecular weight proteins in unoperated and ureter-ligated animals and stresses the importance of using sham-operated animals as controls.
在未手术、假手术、输尿管结扎和肾切除的大鼠中测量了人β2-微球蛋白和（羟甲基-C14）-菊粉的血浆清除率。从输尿管结扎和肾切除大鼠的C14活性曲线判断，尿流梗阻后仍有大量肾小球滤过持续存在。注入肾切除大鼠120分钟后，几乎90%的注入蛋白已从血浆中消失，这表明有相当数量的肾外清除，并且使在输尿管结扎前后评估不同肾脏清除机制的尝试变得无效。假手术导致β2-微球蛋白和菊粉的血浆清除率增加。后一种现象可能解释了在未手术和输尿管结扎动物中低分子量蛋白质消失曲线相似性的早期发现，并强调了使用假手术动物作为对照的重要性。
