Lowenstein Pedro R
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center, Research Pavilion, Room 5093, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Trends Immunol. 2002 Jan;23(1):23-30. doi: 10.1016/s1471-4906(01)02063-4.
The immune system imposes limitations on gene transfer into the brain. Viral vectors injected into the brain's ventricular system elicit innate and adaptive immune responses. However, when injected directly into the brain parenchyma, they elicit only transient inflammation owing to the absence of dendritic cells, which transport antigen to lymph nodes and present it to naive T cells to initiate adaptive immune responses. This article explores the evolutionary and developmental basis of brain immune responses and their implications for viral-vector-mediated neurological gene therapy. Elucidating the cellular and molecular basis of these differential reactions is essential to the long-term success of neurological gene therapy.
免疫系统对基因导入大脑施加了限制。注入脑室系统的病毒载体可引发先天性和适应性免疫反应。然而，当直接注入脑实质时，由于缺乏将抗原转运至淋巴结并将其呈递给初始T细胞以启动适应性免疫反应的树突状细胞，它们仅引发短暂的炎症。本文探讨了大脑免疫反应的进化和发育基础及其对病毒载体介导的神经基因治疗的影响。阐明这些不同反应的细胞和分子基础对于神经基因治疗的长期成功至关重要。
