Haverkate F, Timan G, Nieuwenhuizen W
Eur J Clin Invest. 1979 Aug;9(4):253-5. doi: 10.1111/j.1365-2362.1979.tb00881.x.
It appeared from our previous studies that Ca2+ concentrations comparable to those occurring in blood protect the C-terminal part of the gamma-chain remnants of fibrin(ogen) fragments D against further plasmin attack. This study shows that purified fibrin(ogen) fragments D formed in the presence of Ca2+ ions have anticlotting activity in vitro, whereas shortening of the gamma-chain remnants leads to loss of such activity.
我们之前的研究表明，与血液中出现的钙离子浓度相当的钙离子浓度可保护纤维蛋白（原）片段D的γ链残余物的C末端部分免受进一步的纤溶酶攻击。本研究表明，在钙离子存在下形成的纯化纤维蛋白（原）片段D在体外具有抗凝血活性，而γ链残余物的缩短会导致这种活性丧失。
