利奈唑胺成功治疗耐万古霉素肠球菌脑膜炎：病例报告及文献复习
Successful treatment of vancomycin-resistant enterococcus meningitis with linezolid: case report and review of the literature.
作者信息
Steinmetz M P, Vogelbaum M A, De Georgia M A, Andrefsky J C, Isada C
机构信息
Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
出版信息
Crit Care Med. 2001 Dec;29(12):2383-5. doi: 10.1097/00003246-200112000-00023.
OBJECTIVE
To describe the successful treatment of a case of vancomycin-resistant enterococcus meningitis with linezolid.
DESIGN
Case report and review of the literature.
PATIENTS
The patient is a 35-yr-old man who suffered a cerebellar hemorrhage after embolization of a cerebellar arteriovenous malformation. The patient underwent ventriculostomy drainage and craniectomy. The patient was on broad-spectrum antibiotics for pneumonia including vancomycin. The patient remained febrile and grew vancomycin-resistant Enterococcus faecium from the cerebrospinal fluid.
INTERVENTIONS
The patient was treated with intravenous chloramphenicol without success. On postoperative day 16, the patient was begun on intravenous linezolid.
MAIN RESULTS
The patient received 4 wks of intravenous linezolid with complete eradication of the meningitis.
CONCLUSIONS
Intravenous linezolid appears to be a safe and effective therapy for vancomycin-resistant enterococcus meningitis.
目的
描述利奈唑胺成功治疗1例耐万古霉素肠球菌脑膜炎的病例。
设计
病例报告及文献复习。
患者
患者为一名35岁男性，在小脑动静脉畸形栓塞术后发生小脑出血。患者接受了脑室造瘘引流术和颅骨切除术。患者因肺炎接受包括万古霉素在内的广谱抗生素治疗。患者持续发热，脑脊液培养出耐万古霉素屎肠球菌。
干预措施
患者接受静脉注射氯霉素治疗但未成功。术后第16天，开始对患者静脉注射利奈唑胺。
主要结果
患者接受了4周的静脉注射利奈唑胺治疗，脑膜炎完全根除。
结论
静脉注射利奈唑胺似乎是治疗耐万古霉素肠球菌脑膜炎的一种安全有效的疗法。
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