利奈唑胺治疗耐甲氧西林表皮葡萄球菌引起的脑膜炎
Treatment of meningitis due to methicillin-resistant Staphylococcus epidermidis with linezolid.
作者信息
Krueger Wolfgang A, Kottler Bernd, Will Bernd E, Heininger Alexandra, Guggenberger Heinz, Unertl Klaus E
机构信息
Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, 72076 Tübingen, Germany.
出版信息
J Clin Microbiol. 2004 Feb;42(2):929-32. doi: 10.1128/JCM.42.2.929-932.2004.
Abstract
Methicillin-resistant Staphylococcus epidermidis (MRSE) can cause nosocomial meningitis in the presence of prosthetic devices. Vancomycin is the treatment of choice, but its penetration into the cerebrospinal fluid is poor, especially in cases without severe meningeal inflammation. We successfully used linezolid to treat a case of posttraumatic MRSE meningitis with a low-level inflammatory response. Therapeutic effectiveness was documented microbiologically and by the simultaneous measurement of linezolid levels in serum and cerebrospinal fluid.
摘要
耐甲氧西林表皮葡萄球菌（MRSE）在存在假体装置的情况下可引起医院获得性脑膜炎。万古霉素是首选治疗药物，但其脑脊液穿透性较差，尤其是在没有严重脑膜炎症的情况下。我们成功地使用利奈唑胺治疗了一例伴有低水平炎症反应的创伤后MRSE脑膜炎病例。通过微生物学方法以及同时测量血清和脑脊液中的利奈唑胺水平记录了治疗效果。
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In vitro activities of linezolid combined with other antimicrobial agents against Staphylococci, Enterococci, Pneumococci, and selected gram-negative organisms.利奈唑胺联合其他抗菌药物对葡萄球菌、肠球菌、肺炎球菌及部分革兰阴性菌的体外活性。
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