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[特应性皮炎的发病机制]

[Etiopathogenesis of atopic dermatitis].

作者信息

Oehling A, Jerez J

出版信息

Allergol Immunopathol (Madr). 1975 Jan-Feb;3(1):23-8.

PMID:1180202
Abstract

There is a wide variety of criteria in regard to the etiology of atopic dermatitis of neurodermitis. The allergic factor may play a very important role in its etiology. There is neither a general agreement on the importance of food allergy in this regard. Broadly considered, these patients may evoke intense positive reactions to intradermal tests to food and inhalative allergens, nevertheless it will be possible to establish that the lesions appear or disappear after the exposure of suppression of the antigens which evoked the positive reaction. On this basis, many dermatologists deny the allergic etiology in atopic dermatitis, even though in most instances no food skin tests are performed. In this study, 110 patients, both children and adults of both sexes, suffering from atopic dermatitis are investigated. The onset in most of the cases is before the age of six months, following the ages between 1-10 years; the groups between 6 months and one year, and 10-20 years followed a descending order per decade until 70 years. 60.9% of the cases showed food allergy to one or more food items. In 39% of the cases, no food allergy was found. The food-stuffs more commonly involved were: milk (37.7%), egg (26.3%) and fish (20.9%), followed by coca, wheat flour, seafood, fruits, vegetables and meat. A remission of the reaction followed the suppression of the allergen. Intestinal parasitosis is evaluated in relation to atopic dermatitis. 30.9% of the 110 cases were affected with intestinal parasitosis, being the most common the flagelates (lamblias), protozoa (amoeba) and nematodes (ascaris, tricocephalus and oxijrus). Finally, a concurrence is found between atopic dermatitis and other allergic diseases in 81 cases (73.6%), being bronchial asthma and asthmatic bronchitis the most frequent, and allergic rhinitis, urticaria and Quincke's edema less frequent.

摘要

关于特应性皮炎或神经性皮炎的病因,有各种各样的标准。过敏因素在其病因中可能起着非常重要的作用。在这方面,对于食物过敏的重要性并没有普遍的共识。从广义上讲,这些患者可能对食物和吸入性过敏原的皮内试验产生强烈的阳性反应,然而,有可能确定在引发阳性反应的抗原暴露或抑制后,皮损会出现或消失。基于此,许多皮肤科医生否认特应性皮炎的过敏病因,尽管在大多数情况下并没有进行食物皮肤试验。在这项研究中,对110例患有特应性皮炎的患者进行了调查,包括儿童和成人,男女皆有。大多数病例的发病年龄在6个月之前,其次是1至10岁;6个月至1岁以及10至20岁的年龄段每十年呈下降趋势,直至70岁。60.9%的病例对一种或多种食物表现出食物过敏。在39%的病例中,未发现食物过敏。更常涉及的食物有:牛奶(37.7%)、鸡蛋(26.3%)和鱼类(20.9%),其次是可可、面粉、海鲜、水果、蔬菜和肉类。在过敏原被抑制后,反应有所缓解。对肠道寄生虫病与特应性皮炎的关系进行了评估。110例病例中有30.9%患有肠道寄生虫病,最常见的是鞭毛虫(贾第虫)、原生动物(阿米巴)和线虫(蛔虫、鞭虫和蛲虫)。最后,在81例(73.6%)病例中发现特应性皮炎与其他过敏性疾病并发,其中支气管哮喘和喘息性支气管炎最为常见,过敏性鼻炎、荨麻疹和昆克水肿较少见。

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