Cherr Gregory S, Edwards Matthew S, Craven Timothy E, Levy Pavel J, Ligush John, Geary Randolph L, Plonk George W, Hansen Kimberley J
Division of Surgical Sciences, Section of Vascular Surgery, Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
J Vasc Surg. 2002 Jan;35(1):94-9.
This study assessed the cardiovascular disease, perioperative results, and survival after surgical abdominal aortic aneurysm repair in young patients (< or = 50 years) compared with randomly selected older patients who also underwent abdominal aortic aneurysm repair.
We reviewed hospital records to identify young and randomly selected control patients (3 for each young patient, > or = 65 years, matched for year of operation) with degenerative (atherosclerotic) abdominal aortic aneurysms undergoing repair between Jan 1, 1988, and Mar 31, 2000. Patients with congenital aneurysms, pseudoaneurysms, aortic dissections, post-coarctation dilations, aortic infection, arteritis, or aneurysms isolated to the thoracic aorta were excluded. Mortality data and cause of death were obtained from medical records and the National Death Index
Among 1168 patients who underwent abdominal aortic aneurysm repairs, 19 young patients (1.6%) and 57 control patients were identified. The mean age was 48.4 years in the young group and 72.2 years in the control group. There were no differences in sex or race between the two groups. When comparing existing cardiovascular disease between the groups, there were no differences in the incidence of earlier coronary revascularization (26% vs 16%) or non-cardiac vascular surgery (5% vs 9%), but aneurysms were more commonly symptomatic in young patients (53% vs 21%; P <.01). Aneurysmal disease was limited to the infrarenal aorta in similar proportions of patients (89% vs 88%). No statistically significant differences were seen in the incidence of perioperative deaths (16% young vs 9% control; P =.40) or postoperative complications (37% young vs 26% control; P =.38). The estimated survival rate of the young group was not different from that of the control group (3-year survival rate, 73% vs 69%; P =.32) or the entire cohort of patients (older than 50 years; n = 1101) who underwent repair of abdominal aortic aneurysms during the study period (3-year survival 73% vs 75%; P =.63)
After abdominal aortic aneurysm repair, young patients had perioperative results and follow-up mortality rates similar to those of control patients. Cardiovascular disease was the predominant cause of death after abdominal aortic aneurysm repair in the young patients. When compared with an age older than 50 years at the time of abdominal aortic aneurysm repair, young age alone was not associated with increased survival.
本研究评估了年轻患者(≤50岁)与随机选择的同样接受腹主动脉瘤修复术的老年患者相比,其心血管疾病、围手术期结果及术后生存率。
我们回顾了医院记录,以确定在1988年1月1日至2000年3月31日期间接受退行性(动脉粥样硬化性)腹主动脉瘤修复术的年轻患者及随机选择的对照患者(每名年轻患者对应3名年龄≥65岁的对照患者,按手术年份匹配)。排除患有先天性动脉瘤、假性动脉瘤、主动脉夹层、缩窄后扩张、主动脉感染、动脉炎或仅累及胸主动脉的动脉瘤患者。从病历和国家死亡指数获取死亡率数据及死亡原因。
在1168例接受腹主动脉瘤修复术的患者中,确定了19例年轻患者(1.6%)和57例对照患者。年轻组的平均年龄为48.4岁,对照组为72.2岁。两组在性别或种族方面无差异。比较两组现有的心血管疾病时,早期冠状动脉血运重建发生率(26%对16%)或非心脏血管手术发生率(5%对9%)无差异,但年轻患者的动脉瘤更常出现症状(53%对21%;P<.01)。相似比例的患者动脉瘤疾病局限于肾下腹主动脉(89%对88%)。围手术期死亡率(年轻患者16%对对照患者9%;P = 0.40)或术后并发症发生率(年轻患者%对对照患者26%;P = 0.38)无统计学显著差异。年轻组的估计生存率与对照组(3年生存率,73%对69%;P = 0.32)或在研究期间接受腹主动脉瘤修复术的整个患者队列(年龄大于50岁;n = 1101)(3年生存率73%对75%;P = 0.63)无差异。
腹主动脉瘤修复术后,年轻患者的围手术期结果及随访死亡率与对照患者相似。心血管疾病是年轻患者腹主动脉瘤修复术后的主要死亡原因。与腹主动脉瘤修复时年龄大于50岁相比,仅年轻本身与生存率增加无关。