Constantinidis Christos, Williams Graham V, Goldman-Rakic Patricia S
Department of Neurobiology, Yale University School of Medicine, P.O. Box 208001, 333 Cedar Street, SHM B404, New Haven, Connecticut 06520-8001, USA.
Nat Neurosci. 2002 Feb;5(2):175-80. doi: 10.1038/nn799.
The prefrontal cortex is important in guiding or inhibiting future responses, which requires the temporal integration of events and which provides continuity to the thought process. No cellular mechanism has been proposed to explain how the mental representation of a response or idea is linked to the next. Using simultaneous recordings in monkeys, we revealed inhibitory interactions between neurons active at different time points relative to the cue presentation, delay interval and response period of a working memory task. These findings suggest an important role of inhibition in the cerebral cortex-controlling the timing of neuronal activities during cognitive operations and thereby shaping the temporal flow of information.
前额叶皮质在引导或抑制未来反应方面很重要，这需要对事件进行时间整合，并为思维过程提供连续性。目前尚未提出细胞机制来解释一个反应或想法的心理表征是如何与下一个联系起来的。通过对猴子进行同步记录，我们揭示了在工作记忆任务的提示呈现、延迟间隔和反应期的不同时间点活跃的神经元之间的抑制性相互作用。这些发现表明抑制在大脑皮质中具有重要作用——在认知操作过程中控制神经元活动的时间，从而塑造信息的时间流。
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