Janzing Joost G E, Hooijer Chris, van 't Hof Martin A, Zitman Frans G
Department of Psychiatry, University Hospital Nijmegen, The Netherlands.
Int J Geriatr Psychiatry. 2002 Jan;17(1):1-5. doi: 10.1002/gps.526.
To compare depression in subjects with and without dementia, adjusting for possible confounders.
The results of comparisons of depression between subjects with and without dementia are inconclusive. Probably confounders play a role.
Ninety-one subjects with DSM-III-R dementia and 110 controls without dementia were recruited from homes for the elderly using an identical procedure. The prevalences of AGECAT depressive syndromes, subsyndromes and factors of depressive symptoms were compared adjusting for possible confounders.
(1) Both groups had similar prevalences of AGECAT depressive syndromes, subsyndromes and overall rates of depressive symptoms; (2) subjects with dementia had significantly more 'motivation symptoms'; and (3) there was a trend to a lower prevalence of 'mood symptoms' in subjects with dementia. These results refer to a sample of institutionalised elderly subjects. It is not clear to what extent they can be generalised to subjects living in the community.
The results indicate that it is not AGECAT (sub)syndrome measures of depression but the profile of depressive symptomatology which is affected by dementia.
比较患有和未患有痴呆症的受试者的抑郁情况，并对可能的混杂因素进行调整。
患有和未患有痴呆症的受试者之间抑郁情况比较的结果尚无定论。可能混杂因素起了作用。
采用相同程序从养老院招募了91名患有DSM-III-R痴呆症的受试者和110名未患痴呆症的对照者。对AGECAT抑郁综合征、亚综合征及抑郁症状因素的患病率进行比较，并对可能的混杂因素进行调整。
（1）两组AGECAT抑郁综合征、亚综合征及抑郁症状总体发生率相似；（2）患有痴呆症的受试者有明显更多的“动机症状”；（3）患有痴呆症的受试者“情绪症状”患病率有降低趋势。这些结果来自于机构养老的老年受试者样本。尚不清楚它们能在多大程度上推广到社区生活的受试者。
结果表明，受痴呆症影响的不是AGECAT抑郁（亚）综合征指标，而是抑郁症状的表现。
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