Janzing J G, Bouwens J M, Teunisse R J, Van't Hof M A, Zitman F G
Department of Psychiatry, University Hospital Nijmegen, The Netherlands.
Psychol Med. 1999 Jul;29(4):979-83. doi: 10.1017/s003329179900865x.
Little is known about the effects of depression on the mortality rates of elderly subjects with dementia.
Logistic regression analysis, adjusting for possible confounders, was used to study the associations between GMS-AGECAT derived syndrome and symptom measures and 12-month mortality rates in a cohort of 73 elderly subjects who met the DSM-III-R criteria of dementia with a median MMSE score of 19.
Twenty-three subjects (32%) died within the 12 month follow-up period. A baseline diagnosis of syndromal or subsyndromal depression was associated with increased mortality. At the symptom level mortality was predicted by higher scores on the factor 'mood symptoms'. The effects of interactions between depression measures and severity of dementia were not significant.
Short-term mortality in elderly subjects with less severe dementia is predicted by the presence of (sub) syndromal depression and by mood symptoms. The effects of depression and severity of dementia on the mortality rates seem to be largely independent.
关于抑郁症对老年痴呆症患者死亡率的影响，人们知之甚少。
采用逻辑回归分析，并对可能的混杂因素进行校正，以研究在73名符合DSM-III-R痴呆症标准、简易精神状态检查表（MMSE）中位数得分为19分的老年受试者队列中，基于老年人精神状态和社会功能分组及评价标准（GMS-AGECAT）得出的综合征和症状指标与12个月死亡率之间的关联。
在12个月的随访期内，23名受试者（32%）死亡。综合征性或亚综合征性抑郁症的基线诊断与死亡率增加相关。在症状层面，“情绪症状”因子得分较高可预测死亡率。抑郁症指标与痴呆症严重程度之间的相互作用影响不显著。
（亚）综合征性抑郁症的存在以及情绪症状可预测轻度痴呆老年受试者的短期死亡率。抑郁症和痴呆症严重程度对死亡率的影响似乎在很大程度上是独立的。
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