Böckelmann Irina, Pfister Eberhard Alexander, McGauran Natalie, Robra Bernt-Peter
Institute of Occupational Medicine and Hygiene, Otto-von-Guericke University of Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
J Occup Environ Med. 2002 Jan;44(1):59-65. doi: 10.1097/00043764-200201000-00010.
The aim of this study was to examine whether signs of neurotoxic influence on the autonomic nervous system, after lengthy occupational lead exposure, could be revealed by appropriate cardiac rhythm analysis. A total of 109 male lead-exposed workers and 27 controls were examined in a cross-sectional study. In addition, 17 lead-exposed participants were investigated a second time in a follow-up study 4 years later. Heart rate variability was assessed in rest, strain, and recovery phases. In the cross-sectional study, lead-exposed persons showed a delayed restoration of cardiac rhythm parameters to the initial vegetative state after the strain phase. This effect significantly increased over a period of 4 more years of exposure in the 17 workers participating in the follow-up study. We found vagal depression caused by long-term lead exposure within the current threshold limit value range, which can be interpreted as an adverse effect.
本研究的目的是探讨通过适当的心律分析，能否揭示长期职业性铅暴露后自主神经系统受到神经毒性影响的迹象。在一项横断面研究中，共对109名男性铅暴露工人和27名对照组进行了检查。此外，17名铅暴露参与者在4年后的随访研究中接受了第二次调查。在静息、应激和恢复阶段评估心率变异性。在横断面研究中，铅暴露者在应激阶段后，心律参数恢复到初始自主状态的过程延迟。在参与随访研究的17名工人中，这种效应在超过4年的暴露期内显著增加。我们发现在当前阈限值范围内，长期铅暴露会导致迷走神经抑制，这可被解释为一种不良反应。
