Kumimoto Hiroshi, Hamajima Nobuyuki, Nishimoto Yoshio, Matsuo Keitaro, Shinoda Masayuki, Hatooka Shunzo, Ishizaki Kanji
Central Laboratory and Radiation Biology, Aichi Cancer Center Hospital, Chikusa-ku, Nagoya, Aichi 464-8681, Japan.
Jpn J Cancer Res. 2002 Jan;93(1):1-5. doi: 10.1111/j.1349-7006.2002.tb01193.x.
We have shown that L-myc genotype is associated with the risk of esophageal cancer from smoking and heavy drinking. In this study, we have analyzed the relationship between the L-myc genotypes and lung cancer risk from smoking in 191 Japanese lung-cancer patients and 241 non-cancer controls. The odds ratios (ORs) were markedly higher in SS and LS genotypes than in LL genotype; age-sex-adjusted ORs were 3.19, 2.30 and 0.92, respectively. This result suggests that the L-myc polymorphism may affect the induction of lung cancer by smoking. The OR for smoking in SS-genotype patients diagnosed within 2 years was higher than that in other SS patients, suggesting that smoking-related lung cancer in SS genotype might exhibit a poorer prognosis.
我们已经表明，L-myc基因型与吸烟和大量饮酒导致的食管癌风险相关。在本研究中，我们分析了191例日本肺癌患者和241例非癌症对照中L-myc基因型与吸烟导致的肺癌风险之间的关系。SS和LS基因型的优势比（OR）显著高于LL基因型；年龄-性别调整后的OR分别为3.19、2.30和0.92。这一结果表明，L-myc多态性可能影响吸烟诱导肺癌的过程。在2年内确诊的SS基因型患者中，吸烟的OR高于其他SS患者，这表明SS基因型中与吸烟相关的肺癌可能预后较差。
