King C R, Daly J W
Am J Obstet Gynecol. 1975 Sep 1;123(1):46-50. doi: 10.1016/0002-9378(75)90944-8.
The effect of low-molecular-weight (LMW) dextran as a prophylactic agent in the prevention of pulmonary emboli and deep vein thrombophlebitis was evaluated. Eighty-seven patients were given LMW dextran during and after surgery on a predetermined schedule during the study period. These 87 patients were compared to 103 patients who, in the previous year and a half, received no pharmacologic prophylaxis. In the dextran group there was one suspected pulmonary embolus, no case of deep vein thrombophlebitis, and no death. In the control group there was one case of deep vein thrombophlibitis, seven cases of pulmonary emboli, and three deaths directly attributable to pulmonary emboli.
评估了低分子量（LMW）右旋糖酐作为预防剂在预防肺栓塞和深静脉血栓性静脉炎方面的效果。在研究期间，87例患者在手术期间及术后按照预定方案接受了LMW右旋糖酐治疗。将这87例患者与103例患者进行比较，后者在过去一年半内未接受任何药物预防。在右旋糖酐组中，有1例疑似肺栓塞，无深静脉血栓性静脉炎病例，也无死亡病例。在对照组中，有1例深静脉血栓性静脉炎病例，7例肺栓塞病例，以及3例直接归因于肺栓塞的死亡病例。
