Cisło Maria, Hałasa Jolanta, Wasik Feliks, Nockowski Piotr, Prussak Magdalena, Mańczak Maria, Kuśnierczyk Piotr
Department of Dermatology and Venerology, University of Medicine, Wroclaw, Poland.
Immunol Lett. 2002 Mar 1;80(3):145-9. doi: 10.1016/s0165-2478(01)00317-0.
Psoriasis vulgaris is a multifactorial disease; the strongest association was established with the HLA complex. The actual disease-predisposing gene(s) has not been identified yet, but several genes from this region were examined in addition to HLA-C and -B. However, HLA-linked complement component polymorphic genes were not extensively studied. Therefore, we typed 67 psoriatic patients for alleles of the HLA-linked complement components BF, C4A and C4B. Alleles of C3, encoded on another chromosome, were established in parallel as a negative control. Frequencies in patients were compared with those in unrelated healthy controls, 100 individuals for C4A and C4B, 890 for BF and 4719 for C3 We found no association of BF alleles with disease, similarly to C3. Among C4 alleles, C4B3 was present in 13.4% of patients as compared with 1% of controls (OR, 15.36; 95% CI, 1.897-124.42; P=0.0009), and C4A6 was present in 19.4% of patients versus 7% of controls (OR, 3.20; 95% CI, 1.202-8.508; P=0.0155). The high frequency of C4B*3 in psoriatics has not been described so far. These results suggest a contribution of C4 genes themselves or a closely linked gene to the susceptibility to psoriasis.
寻常型银屑病是一种多因素疾病；与HLA复合体的关联最为紧密。目前尚未确定实际的疾病易感基因，但除了HLA - C和 - B之外，还对该区域的几个基因进行了检测。然而，与HLA相关的补体成分多态性基因尚未得到广泛研究。因此，我们对67例银屑病患者进行了HLA相关补体成分BF、C4A和C4B等位基因的分型。将位于另一条染色体上的C3等位基因作为阴性对照同时进行检测。将患者的基因频率与无关健康对照进行比较，C4A和C4B检测了100人，BF检测了890人，C3检测了4719人。我们发现BF等位基因与疾病无关联，C3也是如此。在C4等位基因中，C4B3在13.4%的患者中出现，而对照组中为1%（比值比，15.36；95%可信区间，1.897 - 124.42；P = 0.0009），C4A6在19.4%的患者中出现，而对照组中为7%（比值比，3.20；95%可信区间，1.202 - 8.508；P = 0.0155）。银屑病患者中C4B*3的高频率目前尚未见报道。这些结果表明C4基因本身或与之紧密连锁的基因对银屑病易感性有影响。
