胆红素-白蛋白结合与游离胆红素

Bilirubin-albumin binding and free bilirubin.

作者信息

Ahlfors C E

机构信息

Division of Neonatology, Department of Pediatrics, California Pacific Medical Center, 3850 California Street, San Francisco, CA 94118, USA.

出版信息

J Perinatol. 2001 Dec;21 Suppl 1:S40-2; discussion S59-62. doi: 10.1038/sj.jp.7210631.

DOI:10.1038/sj.jp.7210631

PMID:11803415

Abstract

The relevance of plasma bilirubin-albumin binding and, in particular, the nonalbumin-bound or "free" bilirubin concentration to neonatal bilirubin toxicity is controversial. The pivotal role that "free" bilirubin played in the bilirubin toxicity that occurred following administration of sulfisoxazole or benzyl alcohol to jaundiced newborns, and the correlation of "free" bilirubin with bilirubin-induced changes in the auditory brainstem response are strong support for measuring "free" bilirubin when evaluating neonatal jaundice. Reliable methods for measuring "free bilirubin" are available, and population reference values are needed to help determine its proper clinical use.

摘要

血浆胆红素与白蛋白的结合，尤其是未与白蛋白结合的或“游离”胆红素浓度与新生儿胆红素毒性的相关性存在争议。“游离”胆红素在黄疸新生儿服用磺胺异恶唑或苯甲醇后发生的胆红素毒性中所起的关键作用，以及“游离”胆红素与胆红素诱导的听觉脑干反应变化之间的相关性，有力地支持了在评估新生儿黄疸时测定“游离”胆红素。现在已有测定“游离胆红素”的可靠方法，还需要群体参考值来帮助确定其合适的临床应用。