Dechant Georg
Max-Planck-Institute of Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany.
Neuron. 2002 Jan 17;33(2):156-8. doi: 10.1016/s0896-6273(02)00564-0.
In this issue of Neuron, show that in rodent SCG neurons NGF activates Ret, the signaling component of the multisubunit GDNF receptor, in vitro and in vivo by a mechanism, which is independent of GFL ligands and GFRalpha coreceptors. NGF-dependent Ret phosphorylation regulates soma size and metabolism but not survival of maturing postnatal sympathetic neurons.
在本期《神经元》杂志中，研究表明，在啮齿动物的颈上神经节（SCG）神经元中，神经生长因子（NGF）在体外和体内通过一种独立于胶质细胞源性神经营养因子（GFL）配体和GFRα共受体的机制激活多亚基胶质细胞源性神经营养因子（GDNF）受体的信号成分Ret。NGF依赖的Ret磷酸化调节出生后成熟交感神经元的胞体大小和代谢，但不影响其存活。
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