Bagri Anil, Marín Oscar, Plump Andrew S, Mak Judy, Pleasure Samuel J, Rubenstein John L R, Tessier-Lavigne Marc
Department of Anatomy, Howard Hughes Medical Institute, CA, USA.
Neuron. 2002 Jan 17;33(2):233-48. doi: 10.1016/s0896-6273(02)00561-5.
We report that Slit proteins, a family of secreted chemorepellents, are crucial for the proper development of several major forebrain tracts. Mice deficient in Slit2 and, even more so, mice deficient in both Slit1 and Slit2 show significant axon guidance errors in a variety of pathways, including corticofugal, callosal, and thalamocortical tracts. Analysis of multiple pathways suggests several generalizations regarding the functions of Slit proteins in the brain, which appear to contribute to (1) the maintenance of dorsal position by prevention of axonal growth into ventral regions, (2) the prevention of axonal extension toward and across the midline, and (3) the channeling of axons toward particular regions.
我们报告称，Slit蛋白家族作为一类分泌型化学排斥分子，对于前脑几条主要神经束的正常发育至关重要。Slit2基因缺陷的小鼠，尤其是Slit1和Slit2双基因缺陷的小鼠，在包括皮质传出、胼胝体和丘脑皮质束等多种神经通路中表现出显著的轴突导向错误。对多种神经通路的分析表明了关于Slit蛋白在大脑中功能的几个普遍规律，这些规律似乎有助于：（1）通过防止轴突向腹侧区域生长来维持背侧位置；（2）防止轴突向中线方向延伸并穿过中线；（3）引导轴突朝向特定区域。
