来自过去的一次冲击：人类Sm蛋白的古老起源

A BLAST from the past: ancient origin of human Sm proteins.

作者信息

Donahue William F, Jarrell Kevin A

机构信息

Department of Pharmacology and Experimental Therapeutics, Boston University Medical Center, 80 East Concord Street, Boston, MA 02118, USA.

出版信息

Mol Cell. 2002 Jan;9(1):7-8. doi: 10.1016/s1097-2765(02)00429-x.

DOI:10.1016/s1097-2765(02)00429-x

PMID:11804580

Abstract

In this issue of Molecular Cell, Zhang et al. and Møller et al. independently report studies of the E. coli Hfq protein, revealing significant sequence similarities with human Sm proteins. Their findings suggest that Hfq, and the Sm and Sm-like (Lsm) proteins, may function in stabilizing interactions between RNA molecules.

摘要

在本期《分子细胞》杂志中，张等人和莫勒等人分别发表了关于大肠杆菌Hfq蛋白的研究报告，揭示了其与人类Sm蛋白存在显著的序列相似性。他们的研究结果表明，Hfq蛋白以及Sm蛋白和Sm样（Lsm）蛋白可能在稳定RNA分子之间的相互作用中发挥作用。