2,4-二硝基甲苯体外代谢的物种比较
A species comparison of 2,4-dinitrotoluene metabolism in vitro.
作者信息
Short R D, Dacre J C, Lee C C
出版信息
Experientia. 1979 Dec 15;35(12):1625-7. doi: 10.1007/BF01953231.
PMID:118052
Abstract
Postmitochondrial supernatants prepared from livers of mice, rats, rabbits, dogs, and monkeys metabolized 2,4-dinitrotulene. The pattern of metabolites was characterized in both sexes of the species examined. In addition, the pattern of metabolites was altered by varying incubation conditions and pretreating male rats with phenobarbital or SKF 525-A.
摘要
从小鼠、大鼠、家兔、狗和猴子的肝脏中制备的线粒体后上清液可代谢2,4-二硝基甲苯。在所研究物种的雌雄两性中均对代谢物模式进行了表征。此外，通过改变孵育条件以及用苯巴比妥或SKF 525-A对雄性大鼠进行预处理，代谢物模式发生了改变。
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