Itoh S, Hiramatsu N, Iwata A, Yoshiya K, Imai S
Division of Radiology, Daiyuukai General Hospital.
Kaku Igaku. 2001 Nov;38(6):689-98.
The noninvasive microsphere (NIMS) method quantifies cerebral blood flow with N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) without blood sampling of a patient, but when a fan beam collimator is used for collecting raw data in single photon emission computed tomography (SPECT), the procedure is complicated because we have to change the collimator. In phantom and clinical studies we investigated the validity of using a fan beam collimator in collecting planar and SPECT raw data.
The phantom study suggested that using a fan beam collimator for planar imaging was feasible because of the image magnification rate and the count rate. Mean cerebral blood flow (mCBF) values obtained by the NIMS method with the fan beam collimator were compared with mCBF simultaneously estimated from the conventional continuous arterial blood sampling (microsphere: MS) method in twenty patients with ischemic cerebral vascular diseases. There was good correlation (y = 1.033x + 8.004, r2 = 0.729, p < 0.01) in mCBF between the fan beam NIMS method and the MS method.
In conclusion, this method for the measurement of CBF was acceptable for routine clinical studies.
无创微球（NIMS）法利用N-异丙基-p-[123I]-碘安非他明（123I-IMP）在无需对患者进行采血的情况下定量脑血流量，但在单光子发射计算机断层扫描（SPECT）中使用扇形束准直器采集原始数据时，由于必须更换准直器，该过程较为复杂。在模型和临床研究中，我们研究了使用扇形束准直器采集平面和SPECT原始数据的有效性。
模型研究表明，由于图像放大率和计数率，使用扇形束准直器进行平面成像是可行的。在20例缺血性脑血管疾病患者中，将使用扇形束准直器的NIMS法获得的平均脑血流量（mCBF）值与通过传统连续动脉采血（微球：MS）法同时估算的mCBF进行比较。扇形束NIMS法与MS法之间的mCBF具有良好的相关性（y = 1.033x + 8.004，r2 = 0.729，p < 0.01）。
总之，这种测量脑血流量的方法对于常规临床研究是可接受的。
