Covas M I, Fitó M, Marrugat J, Miró E, Farré M, de la Torre R, Gimeno E, López-Sabater M C, Lamuela-Raventós R, de la Torre-Boronat M C
Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Mèdica (IMIM), Carrer Dr. Aiguader, 80, 08003 Barcelona, Espagne.
Therapie. 2001 Sep-Oct;56(5):607-11.
Alongside the French paradox, the REGICOR Study (Girona, Spain) has shown another paradox in the Mediterranean area: a high prevalence of cardiovascular risk factors with low incidence of myocardial infarction in the population of Girona, Spain. The antioxidant effects associated with olive oil consumption could explain part of this 'Mediterranean Paradox'. Virgin olive oils processed by two centrifugation phases and with low fruit ripeness have the highest levels of antioxidant content. The total content of phenolic compounds (PC) from virgin olive oil could delay LDL oxidation. The content and nature of olive oil PC have a high influence in the antioxidant capacity of an olive oil. PC from diet could bind human LDL in non-supplemented volunteers. PC from virgin olive oil could bind LDL and tyrosol is bioavailable in humans from ingestion of virgin olive oil in its natural form.
除了法国悖论，REGICOR研究（西班牙赫罗纳）在地中海地区还发现了另一个悖论：西班牙赫罗纳人群中心血管危险因素的患病率很高，但心肌梗死的发病率却很低。与食用橄榄油相关的抗氧化作用可能是这种“地中海悖论”的部分原因。经过两个离心阶段加工且果实成熟度低的初榨橄榄油具有最高水平的抗氧化剂含量。初榨橄榄油中酚类化合物（PC）的总含量可以延缓低密度脂蛋白（LDL）的氧化。橄榄油PC的含量和性质对橄榄油的抗氧化能力有很大影响。饮食中的PC可以在未补充的志愿者体内与人类LDL结合。初榨橄榄油中的PC可以与LDL结合，并且从天然形式的初榨橄榄油摄入后，酪醇在人体内是可生物利用的。
