Ming Z D, Wei W, Hong C, Wei Z, Xiang D W
Department of Pediatric Thoracic and Cardiovascular Surgery, Shanghai Children's Medical Center, Shanghai Second Medical University, People's Republic of China.
J Extra Corpor Technol. 2001 Dec;33(4):223-6.
This study evaluates the effect of balanced ultrafiltration, modified ultrafiltration, and balanced ultrafiltration with modified ultrafiltration on inflammatory mediators in children's open-heart surgery. Eighty children with congenital heart disease were randomly divided into four groups: control group (C group); balanced ultrafiltration group (BUF group); modified ultrafiltration group (MUF group); and balanced ultrafiltration with modified ultrafiltration group (B+M group). Clinical data of these groups were similar. Tumor necrosis factor (TNF), interleukin-8(IL-8), and E-selectin were measured at the beginning of cardiopulmonary bypass (CPB), 30 min later, at the cessation of CPB, at the cessation of MUF (MUF group and B+M group), and 2 hours postoperatively. During CPB, the concentrations of TNF, IL-8, and E-selectin increased significantly in C and MUF groups and did not change significantly in BUF and B+M groups. In the period of MUF, TNF and IL-8 increased; whereas, E-selectin did not change. The study shows that ultrafiltration can filter out the inflammatory mediators, but only BUF can decrease the concentrations of them. Moreover, MUF only can concentrate blood. Combining both techniques has both effects, but the effect of BUF was offset by MUF.
本研究评估平衡超滤、改良超滤以及平衡超滤联合改良超滤对儿童心脏直视手术中炎症介质的影响。80例先天性心脏病患儿被随机分为四组：对照组（C组）；平衡超滤组（BUF组）；改良超滤组（MUF组）；平衡超滤联合改良超滤组（B+M组）。这些组的临床资料相似。在体外循环（CPB）开始时、30分钟后、CPB结束时、MUF结束时（MUF组和B+M组）以及术后2小时测量肿瘤坏死因子（TNF）、白细胞介素-8（IL-8）和E-选择素。在CPB期间，C组和MUF组中TNF、IL-8和E-选择素的浓度显著升高，而BUF组和B+M组中则无显著变化。在MUF期间，TNF和IL-8升高；而E-选择素无变化。研究表明，超滤可滤出炎症介质，但只有BUF能降低其浓度。此外，MUF仅能浓缩血液。两种技术联合应用具有两种效果，但BUF的效果被MUF抵消。
