对稳定型缺血性心脏病患者使用雷米普利治疗6个月后，对心肌缺血无影响。
No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months.
作者信息
Willenheimer Ronnie, Juul-Möller Steen, Forslund Lennart, Erhardt Leif
机构信息
Department of Cardiology, Malmö University Hospital, Lund University, Malmö, Sweden.
出版信息
Curr Control Trials Cardiovasc Med. 2001;2(2):99-105. doi: 10.1186/cvm-2-2-099.
OBJECTIVE
To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia. METHOD: We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (n = 133), ramipril 1.25 mg/day (n = 133), or placebo (n = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1 and 6 months. RESULTS: Relevant baseline variables were similar in all groups. Changes over 6 months in duration of >/= 1 mm ST-segment depression (STD), total ischaemic burden and maximum STD did not differ significantly between the treatment groups. There was no difference in the frequency of adverse events between the groups. CONCLUSION: ACE inhibitor treatment has little impact on incidence and severity of myocardial ischaemia in patients with stable ischaemic heart disease.
目的
评估为期6个月的血管紧张素转换酶（ACE）抑制剂干预对心肌缺血的影响。方法：我们将389例稳定型冠状动脉疾病患者随机分为三组，分别接受每日5毫克雷米普利（n = 133）、每日1.25毫克雷米普利（n = 133）的双盲治疗或安慰剂治疗（n = 123）。在基线时、1个月和6个月后进行48小时动态心电图检查。结果：所有组的相关基线变量相似。治疗组之间在6个月内≥1毫米ST段压低（STD）的持续时间、总缺血负荷和最大STD的变化无显著差异。各组不良事件的发生率无差异。结论：ACE抑制剂治疗对稳定型缺血性心脏病患者心肌缺血的发生率和严重程度影响很小。
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