与DNA片段d(CCTAGG)2复合的抗疟和细胞毒性生物碱隐丹参酮的结晶及初步X射线分析。
Crystallization and preliminary X-ray analysis of the antimalarial and cytotoxic alkaloid cryptolepine complexed with the DNA fragment d(CCTAGG)2.
作者信息
Lisgarten J N, Pous J, Coll M, Wright C W, Aymami J
机构信息
Institut de Biologia Molecular de Barcelona, CSIC, Jordi Girona 18, E-08034 Barcelona, Spain.
出版信息
Acta Crystallogr D Biol Crystallogr. 2002 Feb;58(Pt 2):312-3. doi: 10.1107/s0907444901018960. Epub 2002 Jan 24.
Crystals of the indoloquinoline alkaloid cryptolepine complexed with the DNA fragment d(CCTAGG)(2) have been grown by the hanging-drop technique at 293 K using ammonium sulfate as the precipitating agent. Over a period of three weeks, yellow tapering bullet-shaped crystals grew to maximum dimensions of 0.2 x 0.1 x 0.1 mm. The crystals belong to space group P6(4), with unit-cell parameters a = b = 29.960, c = 39.64 A, alpha = beta = 90, gamma = 120 degrees, and diffract to 1.4 A.
通过悬滴法，以硫酸铵作为沉淀剂，在293 K下培养出了与DNA片段d(CCTAGG)(2)复合的吲哚喹啉生物碱隐丹参酮晶体。在三周的时间里，黄色的锥形子弹状晶体生长到最大尺寸为0.2×0.1×0.1毫米。这些晶体属于空间群P6(4)，晶胞参数为a = b = 29.960，c = 39.64 Å，α = β = 90°，γ = 120°，衍射极限为1.4 Å。
Zotero 插件